Hemez, Colin; Clarelli, Fabrizio; Palmer, Adam C.; Bleis, Christina; Abel, Sören; Chindelevitch, Leonid; Cohen, Theodore; Abel zur Wiesch, Pia (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-24)
Antibiotic-resistant pathogens are a major public health threat. A deeper understanding of how an antibiotic’s mechanism of action influences the emergence of resistance would aid in the design of new drugs
and help to preserve the effectiveness of existing ones. To this end, we developed a model that links bacterial population dynamics with antibiotic-target binding kinetics. Our approach allows ...